The first-ever Investment Round of the World Health Organization (WHO) reached a culminating moment during the G20 Leaders' Summit today in Rio de Janeiro, chaired by the President of Brazil, H.E. Luiz Inácio Lula da Silva. Heads of state and government at the G20 voiced strong support for a sustainably funded WHO, additional financial pledges were announced, and incoming G20 Chair South Africa pledged to maintain a focus in 2025 on sustainably financing the Organization. The support was reflected in the G20 Rio de Janeiro Leaders’ Declaration which said: “We reiterate the central coordinating role of the World Health Organization (WHO) in the global health architecture, supported by adequate, predictable, transparent, flexible and sustainable financing. We support the conducting of the WHO Investment Round as an additional measure for financing the WHO activities.” The Investment Round is raising funds for WHO’s strategy for global health, the Fourteenth General Programme of Work, which can save an additional 40 million lives over the next four years. The Investment Round has succeeded in shifting WHO’s funding model so that it is more predictable, flexible and resilient.  With the pledges received from Australia, Indonesia and Spain at the Leaders’ Summit, WHO has now received pledges of US$ 1.7 billion. Including other signed funding agreements and expected funding from partnerships, WHO has funding of US$ 3.8 billion for the next four years. This means that WHO has raised 53% of the US$ 7.1 billion funding needed, successfully increasing predictability as compared to 2020, when WHO had only 17% of funding secured for its previous strategy. WHO, Member States and partners will continue efforts to cover the remaining gap so the Organization can deliver on the strategy for 2025–2028.  The Investment Round has also successfully broadened WHO’s donor base, improving its funding resilience. Since its launch in May, there have been 70 new pledges from Member States, and philanthropic and private sector donors, 39 of which are contributing voluntary funds for the first time. This is making WHO’s funding more diversified and thus marks a milestone in the Organization’s evolution. Seven of these new donors are low-income countries and 21 are middle-income countries, representing a shift in WHO’s funding base. This shift also demonstrates broad-based recognition of the need to invest in health and in WHO. Forty-six donors have so far pledged more flexible funding, compared to 35 in the last four years, increasing the ability of WHO to use the funds where they are most needed.  Overall, the Investment Round means that WHO can work more efficiently, better plan the implementation of its Strategy and respond even better to crises. It is expected that a number of other governments and donors will pledge to the Investment Round in the coming months.  Quotes:  President of Brazil, H.E. Luiz Inácio Lula da Silva, said: “The World Health Organization represents humanity’s greatest ideals. Investment over the next four years will be repaid many times over in well-being gained. It will set the foundation for future generations.” The Chancellor of the Federal Republic of Germany, Olaf Scholz, said: “The work of the WHO benefits all of us. It needs reliable financing from a broad base. Every contribution counts."  President of France, Emmanuel Macron, said: “The World Health Organization deserves our support, as our unique common, universal, compass to global health. It is the only organization technically and politically able to coordinate our global action, and edict universal norms and advice in the field of health. As part of this Investment Round, WHO is bringing to life a new Academy, open to all health practitioners around the world, to tackle one of the key investment priorities identified during the COVID crisis, which is human capacity in the health sector. In a nutshell, investing in WHO is investing in the strengthening of our response capacity to health crises and in particular to pandemics.”  President of South Africa H.E. Cyril Ramaphosa, who will Chair the G20 Presidency in 2025, said: “We are proud to carry the baton on from Brazil and continue to spotlight the importance of WHO and the need for sustainable financing towards the goal of health for all.” “The WHO Investment Round is about mobilizing the predictable, flexible funding WHO needs to save lives, prevent disease and make the world a healthier and safer place,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “I thank President Lula for his strong support for WHO and for hosting the culmination of the Investment Round during the G20 Leaders’ Summit, and I thank all donors for their contributions. I am grateful to President Ramaphosa for carrying the baton for sustainable financing for WHO into South Africa’s G20 Presidency next year.” 

The World Health Organization (WHO) has granted Emergency Use Listing (EUL) for the LC16m8 mpox vaccine, making it the second mpox vaccine to be supported by WHO following the Director-General’s declaration of an mpox public health emergency of international concern (PHEIC) on 14 August 2024.This decision is expected to facilitate increased and timely access to vaccines in communities where mpox outbreaks are surging. In 2024, cases have been reported across 80 countries, including 19 countries in Africa, based on data as of 31 October 2024. The Democratic Republic of the Congo, the hardest-hit country, recorded a large majority of suspected cases – over 39 000 – as well as more than 1000 deaths.Today’s move is particularly relevant as the Government of Japan has announced that it will donate 3.05 million doses of the LC16m8 vaccine, along with specialized inoculation needles, to the Democratic Republic of the Congo. This is the largest donation package announced to date in response to the current mpox emergency.  LC16m8 is a vaccine developed and manufactured by KM Biologics in Japan. The Technical Advisory Group (TAG) for EUL of vaccines convened to discuss the outcome of the LC16m8 vaccine review, including the product and programmatic suitability assessments. The TAG recommended the vaccine for use in individuals over one year of age as a single dose vaccine, via a multiple puncture technique using a bifurcated needle.“WHO emergency use listing of the LC16m8 vaccine against mpox marks a significant step in our response to the current emergency, providing a new option to protect all populations, including children,” said Dr Yukiko Nakatani, WHO Assistant Director-General for Access to Medicines and Health Products. “Vaccines are one of the important tools to help contain the outbreak as part of a comprehensive response strategy that also includes improved testing and diagnosis, treatment and care, infection prevention control, and engagement and education within affected communities.”WHO’s assessment for EUL is based on information submitted by the manufacturer and review by the Pharmaceuticals and Medical Devices Agency (PMDA), the Japanese regulatory agency of record for this vaccine. The LC16m8 vaccine has been used in Japan during previous mpox outbreaks and was shown to be safe and effective, including in people with well-controlled HIV. The WHO Strategic Advisory Group of Experts (SAGE) on Immunization reviewed available evidence and recommended the use of LC16m8 vaccine in outbreak settings in children and others with a documented high-risk of exposure to mpox. However, minimally replicating vaccines, such as LC16m8, should not be used during pregnancy and in people who are immunocompromised. Immunocompromised persons include those with active cancer, transplant recipients, immunodeficiency, and active treatment with immunosuppressive agents. They also include people living with HIV with a current CD4 cell count of <200 cells µl.The Global Advisory Committee on Vaccine Safety reviewed the updated safety data on LC16m8 on 20 September 2024 and recommended that healthcare workers are provided with training on the use of bifurcated needles to prevent injuries and adverse effects. In light of the changing epidemiology and emergence of new virus strains, it remains important to collect as much data as possible on vaccine safety and effectiveness in different contexts.WHO continues to work closely with manufacturers, global partners and countries to ensure the availability and administration of safe and effective life-saving products.On 13 September 2024, WHO prequalified the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine and expanded its indication to include use in individuals aged 12 years and older on 8 October 2024. Note to editors: WHO Prequalification (PQ) and Emergency Use Listing (EUL) are mechanisms used to evaluate quality, safety and efficacy of medical products, such as vaccines, diagnostics and medicines, and product suitability for use in the contexts of low- and middle-income countries. Products receiving PQ or EUL support decision-making for international, regional and country procurement by UN and partner procurement agencies and Member States. PQ is based on the review of full set of quality, safety and efficacy data on medical products, including risk management plan and programmatic suitability. EUL is a risk benefit assessment to address urgent demands during public health emergencies based on available limited data where the benefits outweigh the risks.

As world leaders arrive in Rio de Janeiro, Brazil, for the G20 Summit this weekend, the city’s iconic Christ the Redeemer statue will be illuminated in the colour teal. The Brazilian advocates behind this effort are among many around the globe joining the World Health Organization (WHO) to mobilize efforts on a worldwide “Day of Action for Cervical Cancer Elimination.” Other countries are marking the day with campaigns to provide human papillomavirus (HPV) vaccination and screening, launching new health policies to align with the world’s first-ever effort to eliminate a cancer, and raising awareness in communities. Four years ago to the day, 194 countries resolved to eliminate cervical cancer and WHO launched a global strategy. Since then, significant progress has been made. At least 144 countries have introduced the HPV vaccine, over 60 countries now include HPV testing in their cervical screening programmes and 83 countries include surgical-care services for cervical cancer in health-benefit packages. “I thank all the health workers who are playing a critical role in this global effort,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “While we are making progress, we still face huge inequities, with women in low-income countries bearing most of the burden. Only with strong leadership and sustained investment can we achieve our shared goal of equitable access for communities most in need.”Marking this campaign for the fourth  year, governments, partners and civil society are organizing various activities and commitments. These include:Chile will announce a pilot for self-collection with HPV testing, which will be incorporated as part of its health care reform and universal primary health care.China: Medical schools and hospitals will host a series of academic lectures, health runs, and illuminations to raise awareness across 31 cities. Democratic Republic of the Congo will host a 3-day forum to launch a national strategy for cervical cancer elimination, concluding with a march through Kinshasa for cervical cancer awareness. Ethiopia, with support from Gavi, will launch an HPV vaccination campaign aiming to reach over 7 million girls.India: Civil society groups in different states will host a series of activities that include awareness campaigns and trainings for health-care professionals.  Ireland will launch its Action Plan to achieve cervical cancer elimination, one year after announcing its goal to achieve this milestone by 2040 on the Day of Action in 2023. Japan’s Ministry of Health, local municipalities, and hospitals will illuminate over 70 landmarks across the country during their annual Teal Blue Campaign.Nigeria will raise awareness through advocacy led by the Nigerian First Ladies Against Cancer. Rwanda will announce its goal to reach the 90-70-90 targets by the year 2027, three years ahead of the WHO goal.South Africa’s Department of Health will roll out health provider trainings in 3 provinces.Push for better testsWHO is launching new guidance on Target Product Profiles (TPPs) for HPV screening tests. This technical product outlines preferred standards for new HPV tests. The tests should be able to function even in remote areas in low- and middle-income country settings where disease burden is highest. The TPPs highlight the importance of tests that give women the option to collect their own samples for testing; and the value of tools that enable HPV testing in settings closer to where women receive care.The new publication aims to support innovation in the HPV testing market, emphasizing high-performance, low-cost, and accessible solutions, particularly transformative in resource-limited settings.Editor’s noteIn 2020, 194 countries resolved to eliminate a cancer for the first time and WHO launched the Global strategy to eliminate cervical cancer as a public health problem. This historic response to the WHO Director-General’s call to action in 2018 catalyzed a social movement and sparked an annual tradition, bringing communities across the world together for a Day of Action for Cervical Cancer Elimination.  

Worldwide, there were an estimated 10.3 million cases of measles in 2023, a 20% increase from 2022, according to new estimates from the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC). Inadequate immunization coverage globally is driving the surge in cases.Measles is preventable with two doses of measles vaccine; yet more than 22 million children missed their first dose of measles vaccine in 2023. Globally, an estimated 83% of children received their first dose of measles vaccine last year, while only 74% received the recommended second dose.Coverage of 95% or greater of two doses of measles vaccine is needed in each country and community to prevent outbreaks and protect populations from one of the world’s most contagious human viruses.“Measles vaccine has saved more lives than any other vaccine in the past 50 years,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “To save even more lives and stop this deadly virus from harming the most vulnerable, we must invest in immunization for every person, no matter where they live.”“The number of measles infections are rising around the globe, endangering lives and health,” CDC Director Mandy Cohen said. “The measles vaccine is our best protection against the virus, and we must continue to invest in efforts to increase access.”As a result of global gaps in vaccination coverage, 57 countries experienced large or disruptive measles outbreaks in 2023, affecting all regions except the Americas, and representing a nearly 60% increase from 36 countries in the previous year. The WHO African, Eastern Mediterranean, European, South-East Asia and Western Pacific regions experienced a substantial upsurge in cases. Nearly half of all large or disruptive outbreaks occurred in the African region.An unacceptable death toll due to rising measles casesThe new data show that an estimated 107 500 people, mostly children younger than 5 years of age, died due to measles in 2023. Although this is an 8% decrease from the previous year, far too many children are still dying from this preventable disease. This slight reduction in deaths was mainly because the surge in cases occurred in countries and regions where children with measles are less likely to die, due to better nutritional status and access to health services.Even when people survive measles, serious health effects can occur, some of which are lifelong. Infants and young children are at greatest risk of serious complications from the disease, which include blindness, pneumonia, and encephalitis (an infection causing brain swelling and potentially brain damage).As measles cases surge and outbreaks increase, the world’s elimination goal, as laid out in Immunization Agenda 2030, is under threat. Worldwide, 82 countries had achieved or maintained measles elimination at the end of 2023. Just this week, Brazil was reverified as having eliminated measles, making the WHO Americas Region once again free of endemic measles. With the exception of the African Region, at least 1 country in all WHO regions has eliminated the disease.Urgent and targeted efforts by countries and partners, particularly in the African and Eastern Mediterranean regions, and in fragile, conflict-affected and vulnerable settings, are needed to vaccinate all children fully with two doses of measles vaccine. This requires achieving and maintaining high-performing routine immunization programmes and delivering high-quality, high-coverage campaigns when those programmes are not yet sufficient to protect every child. Countries and global immunization partners must also strengthen disease surveillance, including the Global Measles Rubella Laboratory Network (GMRLN). Strong disease surveillance is critical to optimizing immunization programmes and detecting and responding rapidly to measles outbreaks in order to mitigate their size and impact. Note to editorsProgress Toward Regional Measles Elimination — Worldwide, 2000–2023 is a joint publication of WHO and CDC. It is published within the WHO Weekly Epidemiological Record and in CDC’s Morbidity and Mortality Weekly Report. CDC and WHO use statistical modelling to estimate measles cases and deaths each year, based on cases reported by countries, and revise previous year's estimates to assess disease trends over time.CDC and WHO are founding members of the Measles & Rubella Partnership (M&RP), a global initiative to stop measles and rubella. Under the umbrella of Immunization Agenda 2030 and guided by the Measles and Rubella Strategic Framework 2030, M&RP’s mission includes addressing the decline in national vaccination coverage, hastening the recovery of the measles backsliding resulting from COVID-19 pandemic, and accelerating progress towards creating a world free of measles and rubella. The partnership also includes  American Red Cross, Bill & Melinda Gates Foundation, Gavi, the Vaccine Alliance, United Nations Foundation, and UNICEF.Measles elimination is defined as the absence of endemic measles virus transmission in a region or other defined geographical area for more than 12 months. Conversely, a country is no longer considered to be measles free if the virus returns and transmission is sustained continuously for more than a year.For more information on CDC’s global measles vaccination efforts, visit https://www.cdc.gov/global-measles-vaccination.For more information on WHO’s measles response and support, visit https://www.who.int/news-room/fact-sheets/detail/measles. 

The number of adults living with diabetes worldwide has surpassed 800 million, more than quadrupling since 1990, according to new data released in The Lancet on World Diabetes Day. The analysis, conducted by the NCD Risk Factor Collaboration (NCD-RisC) with support from the World Health Organization (WHO), highlights the scale of the diabetes epidemic and an urgent need for stronger global action to address both rising disease rates and widening treatment gaps, particularly in low- and middle-income countries (LMICs).“We have seen an alarming rise in diabetes over the past three decades, which reflects the increase in obesity, compounded by the impacts of the marketing of unhealthy food, a lack of physical activity and economic hardship," said WHO Director-General Dr Tedros Adhanom Ghebreyesus. “To bring the global diabetes epidemic under control, countries must urgently take action. This starts with enacting policies that support healthy diets and physical activity, and, most importantly, health systems that provide prevention, early detection and treatment.”The study reports that global diabetes prevalence in adults rose from 7% to 14% between 1990 and 2022. LMICs experienced the largest increases, where diabetes rates have soared while treatment access remains persistently low. This trend has led to stark global inequalities: in 2022, almost 450 million adults aged 30 and older – about 59% of all adults with diabetes – remained untreated, marking a 3.5-fold increase in untreated people since 1990. Ninety per cent of these untreated adults are living in LMICs.The study further reveals substantial global differences in diabetes rates, with the prevalence of diabetes among adults aged 18 and older around 20% in the WHO South-East Asia and the Eastern Mediterranean Regions. These two regions, together with the African Region, have the lowest rates of diabetes treatment coverage, with fewer than 4 in 10 adults with diabetes taking glucose-lowering medication for their diabetes.WHO’s commitment to global diabetes responseAddressing the soaring diabetes burden, WHO is also launching a new global monitoring framework on diabetes today.  This product represents a crucial step in the global response, providing comprehensive guidance to countries in measuring and evaluating diabetes prevention, care, outcomes and impacts. By tracking key indicators such as glycaemic control, hypertension and access to essential medicines, countries can improve targeted interventions and policy initiatives. This standardized approach empowers countries to prioritize resources effectively, driving significant improvements in diabetes prevention and care.WHO’s Global Diabetes Compact, launched in 2021, includes the vision of reducing the risk of diabetes, and ensuring that all people who are diagnosed with diabetes have access to equitable, comprehensive, affordable and quality treatment and care. The work undertaken as part of the Compact will also support the prevention of type 2 diabetes from obesity, unhealthy diet and physical inactivity. In addition, the same year, a diabetes resolution was endorsed at the World Health Assembly urging Member States to raise the priority given to the prevention, diagnosis and control of diabetes as well as prevention and management of risk factors such as obesity.In 2022, WHO established five global diabetes coverage targets to be achieved by 2030. One of these targets is to ensure that 80% of people with diagnosed diabetes achieve good glycemic control. Today’s release underlines the scale and urgency of action needed to advance efforts to close the gap.  The upcoming year 2025 presents a significant opportunity to catalyse action against the alarming rise in diabetes worldwide with the Fourth High-level Meeting of the United Nations General Assembly on the prevention and control of noncommunicable diseases (NCDs) to take place in September. This meeting brings heads of states and governments together to set a powerful vision for preventing and controlling NCDs, including diabetes, through a collective commitment to address root causes and improve access to detection and treatment. By aligning efforts towards the 2030 and 2050 goals, this high-level meeting is a pivotal moment for strengthening global health systems, including primary health care and halting the rise in the diabetes epidemic. Notes for editorsThe study released today was conducted by the NCD Risk Factor Collaboration (NCD-RisC), a worldwide network of over 1500 researchers and practitioners, in collaboration with WHO. It is the first global analysis of trends in both diabetes rates and treatment coverage that is based on data from over 140 million people aged 18 years or older that were included in more than 1000 studies covering populations in all countries. The study used an updated methodology of measuring diabetes prevalence in populations from previous studies to provide a more accurate overview of the global diabetes epidemic.